Your Enshrouded settings keep changing back

The panel writes four values into the server's config file every time the server starts: the Server Name, the Server Password, the player limit and the port. Whatever you type over them in enshrouded_server.json is replaced. Change them in the panel instead.

Where to change each one

Then restart the server so the change takes effect.

Everything else

Difficulty, chat, permissions and the Admin password are on Settings, Gameplay Settings. Changes saved there stay: the game does not overwrite the file when it stops.

Use Save & restart to apply at once, or Save only to wait for the next restart. See How to set up your Enshrouded server.

If a Gameplay Settings change has no effect

The difficulty values apply only when Difficulty preset is Custom: see Your Enshrouded custom difficulty settings do nothing.